A fight broke out among the heroes for possession of the box and was only ended when John Constantine took the box, being the only one capable of doing so without being corrupted. Zatanna and Constantine took the box to the temple of Hephaestus, where the three Justice Leagues had converged again. After yet another battle between heroes, the box went dormant and the Justice Leagues discovered a Kryptonite sliver in Superman’s nervous system, placed there by the Atomica, a traitor working for the Outsider, leader of the Secret Society. Then, the Outsider used the box to open a path across universes, allowing the Crime Syndicate to enter the Justice Leagues' world.
In August 2010 (issue #600), J. Michael Straczynski took over the series' writing duties and introduced Wonder Woman to an alternate timeline created by the Gods in which Paradise Island had been destroyed and the Amazons scattered around the world. In this timeline, Diana is an orphan raised in New York. The entire world has forgotten Wonder Woman's existence and the main story of this run was of Diana trying to restore reality even though she does not properly remember it herself. A trio of Death Goddesses called The Morrigan acted as the main enemy of Wonder Woman. In this run, Wonder Woman wears a new costume designed by Jim Lee. Straczynski determined the plot and continued writing duties until Wonder Woman #605; writer Phil Hester then continued his run, which ultimately concluded in Wonder Woman #614.