A version of the Cheetah appears in the "Odyssey" storyline, which involves the Gods altering Diana's history so that Themyscira was destroyed when she was a child. The new Cheetah is created from the corpse of a murdered Amazon after it is lowered into a mystical restoration pit and infused with the spirit of Magaera by the Morrigan (the villains who are hunting Wonder Woman). Alongside new versions of Artemis and Giganta (both of whom are also created from dead Amazons), the new Cheetah is tasked with hunting down and killing Wonder Woman. After tracking down the safehouse where Diana lives with the last surviving residents of Themyscira, Cheetah brutally ambushes and slays a young Amazon as she steps outside. Cheetah is then shown carrying the woman's body away from the scene, muttering about how she too will be reborn soon.
Orion brings them to New Genesis where Diana has learned she has been in a coma for three days.Angered by this, she goes to talk to Highfather but realizes that in doing so, he saved her life. He informs her Orion is meditating in order to control his anger. After a heart to heart talk among each other, Diana finds out that Highfather will allow them to escape, on the condition that they surrender the baby. Diana, disappointed tries to remind Orion what she's done for him. Orion apologizes to Highfather and follows them through the boomtube with Zeke in tow, although Highfather says that their is no need.
During the story-arc written by Jodi Picoult in issues #6–10, and which ties into Amazons Attack!, Diana is captured and imprisoned by the Department of Metahuman Affairs, led by an imposter Sarge Steel. She is tortured and interrogated to garner information that will allow the United States government to build a Purple Death Ray previously used during Infinite Crisis.
In 2011, DC relaunched its comic books and rebooted its continuity in an initiative called The New 52. The character was re-made to be a corrupt image and antecedent to Wonder Woman. Barbara Ann Minerva (having used several aliases that happen to be the names of the various incarnations of the character) is reintroduced as Cheetah. As part of her new backstory, Minerva is referred to as an accomplice to Wonder Woman and an expert in dangerous relics, and having previously grown up in an all-woman commune called "Amazonia". In the possession of a dagger once belonging to a lost tribe of Amazons, she cut herself on it. She was possessed by the Goddess of the Hunt, transforming her into a human-cheetah hybrid. Her claws can also turn Superman into a cheetah-like being. The origin of the Cheetah is dated back to the San Tribe, who for centuries had hunted alongside the cheetahs. Every generation, one of their members is chosen to become the host of the Goddess of the Hunt, until one day a hunter killed the current host; the knife used to kill her was cursed until it fell in the hands of Minerva. Cheetah is subdued by the Justice League and placed in Belle Reve. However, once there, she makes contact with someone telling him she is where he requested, implying her capture was staged as a part of a bigger plan.