Since her attack on Veronica Cale, Cheetah had been captured by Cale and held in the basement of Empire Industries, where she was being experimented on by Doctor Poison. Cheetah suddenly dropped into a coma, before waking and massacring Empire Industries' staff, while screaming about the return of the so-called 'Dark Gods'. She attempted to kill Cale once again, but was restrained due to the timely intervention of Wonder Woman. Steve Trevor informed Diana that all over the world, people had begun acting strangely and warning of the Dark Gods. As she flew through the skies of Washington, she was suddenly attacked by a deranged Supergirl. After a lengthy battle, Wonder Woman was able to defeat Kara and restrained her in the Lasso of Truth, which knocked her unconscious. Jason returned after learning from the Fates that the armor that had been gifted to him by the gods was originally created for Diana, but had been mistakenly given to Jason after Zeus' death. It also allowed Jason to channel the power of any member of the Greek Pantheon, though he could only use one god's powers at a time. Jason began to explain his discoveries to Diana, but they were interrupted by a group of giant monoliths appearing in the sky, which began to activate. As soon as the siblings began to investigate, Wonder Woman was taken by a pair of Star Sapphires who needed her assistance due to an emergency on Zamaron. As Diana was forcefully teleported, Jason was left alone before the activating monoliths.
At the end of the 1960s, under the guidance of Mike Sekowsky, Wonder Woman surrendered her powers in order to remain in Man's World rather than accompany her fellow Amazons to another dimension. Wonder Woman begins using the alias Diana Prince and opens a mod boutique. She acquires a Chinese mentor named I Ching, who teaches Diana martial arts and weapons skills. Using her fighting skill instead of her powers, Diana engaged in adventures that encompassed a variety of genres, from espionage to mythology. This phase of her story was directly influenced by the British spy thriller The Avengers and Diana Rigg's portrayal of Emma Peel.
Wonder Woman and Hermes briefly returned to Themyscira so that Diana could pay her respects to her petrified mother. When they got back to her apartment, they found Hera crying and mourning the days when she used to be a goddess. As Diana comforted her, she realized she would need help in finding Zola and Zeke. Wonder Woman went to the Taiga, Siberia, where she asked Artemis for her help. Artemis agreed, on the condition that she and Diana have a rematch. Knowing they are in Artemis' realm, Diana threw the fight in Artemis' favor.
The first of these half-mortal siblings to reveal himself to Wonder Woman was her older half-brother, Lennox Sandsmark, who could transform himself into living, marble-like stone and, before his death, was revealed to be the father of Wonder Girl (Cassie Sandsmark). His killer, the First Born, the eldest progeny of Zeus, would become Wonder Woman's first major super-villain of the New 52.
Wonder Woman managed to stabilize the plane when it was hit by the shockwave. Hermes and Artemis also arrived at Olympus, where Artemis discovered that Apollo had died in the attack. Among the ruins of the tower, the First Born claimed the throne of Olympus. Wonder Woman confronted the First Born, but he gained the upper hand. However, Hera arrived at Olympus, having regained her Olympian powers, revealing that Apollo had restored them before dying. Hera teleported Wonder Woman and her allies to Paradise Island. There, Wonder Woman found Zola, safe. Hera had also restored the Amazons back to life. Wonder Woman chose to lead them to battle as the new God of War.
After defeating Giganta in battle, Wonder Woman was approached by a lawyer who informed her that she had inherited the estate of Hercules, who had been killed. Shortly thereafter, she was told by A.R.G.U.S. that Hercules' body came from an area containing traces of energy unique to Apokolips. Diana visited Hercules' home and found a letter addressed to her, informing her of the location of her twin brother, Jason. She found him in Greece, and the two seemingly began to bond, only for Jason to turn against Diana after the arrival of Grail, who he had secretly allied himself with. Grail had begun killing children of the earthly gods in order to use their divine power to restore her father Darkseid to adulthood, as he had been turned into a baby at the end of the Darkseid War. Jason allied himself with her in order to exact revenge on Wonder Woman, as he resented her for not seeking him out after she learned of his existence some time ago and was envious of her. However, as Darkseid was about to drain Diana's life force, Jason regretted his actions and joined Wonder Woman in battle against Grail and Darkseid. Then, Hercules' lawyer revealed his true identity as the King of the Gods himself, Zeus. Zeus fought Darkseid while Wonder Woman took on his daughter, Grail. Ultimately, Zeus was defeated and his life force was drained by Darkseid, restoring the Apokoliptian to his full adult form. The Justice League arrived, forcing Darkseid and Grail to retreat through a Boom Tube. In the aftermath of the battle, Diana forgave her brother for his deceit.
Trudging on, Hades expects their presence and tries sending spirits in order to stall and attack Diana and Hermes. Successfully defeating them, they wonder through a forest and find a cabin resembling Zola's farm house. Zola pops out and happily hugs Wonder Woman. Hades at that moment makes his grand entrance and frees them. Though, just before they escape, Hades beckons Wonder Woman to look behind, and shoots her with Eros pistols. She urges Hermes and Zola to leave while she is left at the mercy of Hades who wants her to be his bride. Here, she is preparing to wed Hades when she gives Diana her lasso, saying that if he truly loves him, she will confess it due to the properties of the lasso. She says yes, but will not go on with the wedding as it is more or less forced and not real love. She escapes his clutches and shoots him as a means of payback for shooting her.